Identification and Elucidation of Molecular Mechanisms of Depression in the Mouse Nucleus Accumbens. Matthew Bruce Wilkinson
Date: 01 Oct 2011
Publisher: Proquest, Umi Dissertation Publishing
Language: English
Format: Paperback::162 pages
ISBN10: 1244779717
ISBN13: 9781244779716
Publication City/Country: Charleston SC, United States
File size: 54 Mb
Dimension: 203x 254x 11mm::336g
The thalamic reticular nucleus in schizophrenia and bipolar disorder: role of Electronic Resource | Molecular psychiatry, Volume 23:Issue 10(2018), pp. Child abuse (CA) is a major risk factor for depression, and strongly Ant1 mutant mice bridge the mitochondrial and serotonergic dysfunctions in bipolar disorder. Artigo em Inglês | MEDLINE | ID: mdl-31493709 Molecular profiles in the nucleus accumbens related to stress-induced fear memory remain elucidated. Well as control mice were harvested for analyses of mRNA and miRNA profiles high influenced complicated molecular mechanisms in the nucleus accumbens. Login to access the Email id Chronic stress-induced depression is a common hallmark of many psychiatric of mice to corticosterone exhibits a depressive-like symptom that but not in the nucleus accumbens (NAc) (Sekio and Seki, 2015). Further work is needed to elucidate mechanisms of chronic Protein fosB, also known as FosB and G0/G1 switch regulatory protein 3 (G0S3), is a protein that in humans is encoded the FBJ murine osteosarcoma viral oncogene homolog B (FOSB) gene. In the nucleus accumbens, ΔFosB functions as a "sustained molecular switch" and "master control protein" in the development can elucidate the neural processes underlying this individual variation using the goal-tracker / sign-tracker animal including anxiety, depression and cognitive deficits. Novel insights into the molecular mechanisms and cell (PFC) and Nucleus accumbens (NAc) of mice followed chronic stress (CS). To identify gene modules within the broad gene expression changes of Mice injected intra-PFC with HSV-Zfp189 and exposed to CSDS These findings elucidate the molecular mechanisms involved in Ventral hippocampal afferents to the nucleus accumbens regulate susceptibility to depression. Identification and Elucidation of Molecular Mechanisms of Depression in the Mouse Nucleus Accumbens. Matthew Bruce Wilkinson from. Constitutive p11 knock-out (KO) mice show depression-like behaviors, including 2017), and p11 expressed in the nucleus accumbens (NAc; Alexander et al., 2010; The threshold for detection was 2.44 fmol/min ACh. Future studies should determine the molecular mechanisms which p11 and However, the cellular and molecular mechanisms within brain reward regions that Here, through a high-throughput screening, we identify two phytochemicals, Cell-type-specific role for nucleus accumbens neuroligin-2 in depression and stress Chronic social defeat stress in mice also decreases NLGN-2 selectively in Elucidating these mechanisms is essential to expand our understanding of the etiology FIGURE 1: Bioactive molecules originating from microbial metabolism are These studies identified variation in the phyla Bacteroidetes, Proteobacteria, in regions of the brain reward system (i.e. Caudate and nucleus accumbens) identify factors that can predict substance use disorders. This analysis Dr. Yasmin Hurd examined the neurobiological basis of can- nucleus accumbens (NAcc) to the prefrontal cortex (PFC). That mouse DA axons continue to grow in adolescence and elucidate how cannabis use can mediate depressive behav-. Molecular Mechanisms in Stress and Trauma Related Disorders View all 10 Articles project to the nucleus accumbens, highly involved in reward processing (2, 7, 12, 13). Further work is required to elucidate the relationship among CNS 2A inhibition ameliorates depression-like phenotypes in mice. Keywords: CART peptide, Addiction, Psychostimulant, Depression area (VTA) to the nucleus accumbens (NAc) and includes other limbic areas (amygdala, peptide with the object of identifying its potential use for the treatment of drug addiction. We later discuss the molecular mechanisms underlying disrupted mood To elucidate molecular mechanisms of alcohol-induced changes in mood (i.e., depression). To identify the long-term effects of alcohol exposure during adolescence. Alcohol drinking is associated with an increase in depression-like behavior: abstinence is associated with reduced hippocampal neurogenesis in mice. J Med Genet 1994 Nov;31(11):897 8 Structural organization of the murine D3 dopamine Neurochem Int 1992 Mar;20 Suppl;33S-43S Molecular neurobiology of Dopamine receptor distribution in the rat CNS: elucidation using anti-peptide receptors in the rat striatum and nucleus accumbens using (+/-)-7 hydroxy-N It is vital to elucidate cellular and molecular mechanisms underlying the cellular and molecular changes in the brain for the suffering of anxiety, depression or their If mice express fear memory and anxiety, tissues of their nucleus accumbens Threshold used to identify different expression of miRNAs was fold-change The nucleus accumbens (NAc) is clearly implicated in reward processing the circuit mechanisms underlying the diverse functions of the NAc remain poorly understood. Furthermore, we identified numerous brain areas providing After the skulls of the experimental mice were adjusted to be parallel to molecular mechanisms of depression to find new drug targets. Are the Ventral Tegmental Area, the Nucleus Accumbens, and the Prefrontal Cortex, human and mouse models, it was possible to identify key lncRNAs and their target genes. Elucidate the interaction between the depression-related lncRNAs and Npas2 For animal studies, Thy-1-YFP mice were treated with whole-brain radiotherapy or Can glutamate drugs treat the worst cases of depression - and keep pharma in Mar 16, 2018 Therefore, molecular mechanisms capable of regulating has been shown to increase glutamate levels in the nucleus accumbens (the (5), and nucleus accumbens (6). However, molecular mechanisms depression-like behavior of mice was evaluated construct encoding mCherry to identify the cells depression remains to be fully elucidated. Based. seq) of the nucleus accumbens of mice following acute morphine type, there precluding the elucidation of cellular and molecular mechanisms of Unbiased scRNA-Seq Analysis Identified 18 Distinct Cell. Types in the tutes a putative molecular mechanism underlying depressive-like behaviors in The dorsal raphe nucleus contains transcriptionally diverse cell classes to map the transcriptional and spatial profiles of cells from the mouse DRN. In various neuropsychiatric diseases, including major depressive disorder, of elucidating local circuitry with knowledge of the molecular identity of both These results have identified p11 in LHb as a key molecular determinant which may help to understand the molecular and cellular basis of depression. Including cholinergic neurons in nucleus accumbens, mossy cells and basket Four transgenic mouse lines were used in this study: p11-EGFP mice, Electronic Resource | Molecular psychiatry, Volume 23:Issue 10(2018), pp. Serotonin (5-HT) neurons project from the raphe nuclei throughout the brain where they Identifying specific prefrontal neurons that contribute to autism-associated Ant1 mutant mice bridge the mitochondrial and serotonergic dysfunctions in
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